HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes.{19457} HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally (10 mg/kg).{19457}
产品描述
A potent, reversible 5-LO inhibitor, blocking LTB4 synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes; also attenuates LTB4 synthesis, prevents carrageenan-induced pleurisy, and protects against PAF-induced shock in mice when given intraperitoneally