- 中文名称
MLL1/WAR complex -human recombinant) (250 ug)
- 英文名字
- Mixed-Lineage Leukemia-1|MLL Core Complex, MLL1/WAR complex -human recombinant)
- 供应商
- Cayman
- 产品货号
- 10756-250
- 产品报价
- ￥19446/250 ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- The MLL complex methylates histone 3 at lysine 4 -H3K4) to upregulate transcription. MLL1 is the catalytic subunit which exhibits a low basal methyltransferase activity. Addition of WDR5, Ash2L, and RbBP5 -WAR) enhances Histone H3K4 methylation 300-fold; an additional 2-fold activation has been reported for the addition of DPY-30 -Item No. 11178 and Item No. 10945). The MLL core complex colocalizes with RNA Polymerase II on chromosomes and is involved in the transition of paused Pol II to actively-transcribing Pol II. Misregulation of MLL1 by fusion of its non-catalytic N-terminus to any of >50 other proteins leads to leukemia, possibly due to release of paused Pol II at developmentally important sites such as the Hox family of genes. Wild-type MLL1 is targeted to Hox genes through interactions with menin, and is thus important for proper development.,The Cayman MLL1/WAR complex is supplied as four tubes. Combining the four tubes will result in an equimolar ratio of MLL1, WDR5, Ash2L, and RbBP5.
- 产品描述
- Source: Active recombinant proteins expressed in E. coli
- 产品形式
- 保存建议
- -80
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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