Cathepsin D is a lysosomal aspartic protease of the pepsin family. Mouse Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 120), a propeptide (residues 21-64), and a mature chain (residues 65-410). It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells is responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
应用类型
WB
免疫原
该Anti-Mouse Cathepsin D的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Mouse Cathepsin D的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Mouse Cathepsin D的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Mouse Cathepsin D的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
