- 中文名称
Anti-Mouse Angiopoietin-like protein 3
- 英文名字
- Anti-Mouse Angiopoietin-like protein 3
- 供应商
- ReliaTech
- 产品货号
- 103-M307
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins.Mature mouse ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated Nand C-terminal fragments containing the coiled coil domain and fibrinogenlike domains, respectively. ANGPTL3 is found as 70 kDa, 50 kDa, and 32 kDa species and can form weakly associated noncovalent multimers in vitro. ANGPTL3 directly inhibits lipoprotein lipase (LPL), an enzyme responsible for hydrolyzing circulating triglycerides. This activity requires a putative heparinbinding motif that is N-terminal to the coiled coil domain. Proteolytic removal of the fibrinogenlike domain from the N-terminal fragment serves to activate ANGPTL3 and increase its ability to inhibit LPL in vitro and function in vivo. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 knockoutmice are hypolipidemic and have elevated LPL activity. ANGPTL3 expression in vivo is upregulated by LXR agonists and downregulated by insulin, leptin, and TRβ agonists. Dysregulated ANGPTL3 expression and elevated plasma triglyceride levels are characteristic of some strains of obese and diabetic mice, ANGPTL3 does not bind Tie1 or Tie2 but its fibrinogenlike domain interacts with integrin αVβ3 to induce endothelial cell adhesion, migration, and neovascularization. ANGPTL3, secreted by fetal liver cells, also promotes the expansion of hematopoietic stem cells. Mature mouse ANGPTL3 shares 22%-30% amino acid (aa) sequence identity with ANGPTL 1, 2, 4, 6, and 7. It shares 77% aa sequence identity with human ANGPTL3.
- 应用类型
- ELISA
- 免疫原
- 该Anti-Mouse Angiopoietin-like protein 3的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Mouse Angiopoietin-like protein 3的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Mouse Angiopoietin-like protein 3的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Mouse Angiopoietin-like protein 3的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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