- 中文名称
Anti-Human FAS Ligand, soluble
- 英文名字
- Anti-Human FAS Ligand, soluble
- 供应商
- ReliaTech
- 产品货号
- 102-P120G
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Both mouse and human Fas Ligand are active on mouse and human cells. Fas Ligand is expressed on the cell surface as a nondisulfidelinked homotrimer on activated CD4+ Th1 cells, CD8+ cytotoxic T cells, and NK cells. Fas Ligand binding to Fas/CD95 on an adjacent cell triggers apoptosis in the Fas expressing cell. Fas Ligand also binds DcR3 which is a soluble decoy receptor that interferes with Fas Ligandinduced apoptosis. Fas Ligand can be released from the cell surface by metalloproteinases as a 26 kDa soluble molecule which remains trimeric. Shed Fas Ligand retains the ability to bind Fas, although its ability to trigger apoptosis is dramatically reduced. In the absence of TGFβ, however, Fas Ligand/Fas interactions instead promote neutrophilmediated inflammatory responses. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigenstimulated T cells. Fas Ligandinduced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. This function is exploited by tumor cells which evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lympho-proliferation and systemic autoimmunity.
- 应用类型
- ELISA, WB, N
- 免疫原
- 该Anti-Human FAS Ligand, soluble的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- Goat
- 反应性
- 该Anti-Human FAS Ligand, soluble的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Human FAS Ligand, soluble的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
