- 中文名称
Anti-Human FGFR-4
- 英文名字
- Anti-Human FGFR-4
- 供应商
- ReliaTech
- 产品货号
- 101-M418
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase. Mature human FGF R4 consists of a 348 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 412 aa cytoplasmic domain that contains the tyrosine kinase domain. Within the ECD, human FGF R4 shares 90% and 88% aa sequence identity with mouse and rat FGF R4, respectively. Alternate splicing generates a potentially secreted isoform with a substitution encompassing the transmembrane segment. A 65 kDa N-terminally truncated isoform lacks the signal peptide and first two Ig-like domains. This isoform is produced in human pituitary adenomas and is constitutively phosphorylated and oncogenic. FGF R4 is widely expressed during embryonic development and in adult liver, kidney, and lung. It binds FGF acidic, FGF basic, FGF8, 15, and 19. FGF R4 associates with betaKlotho and sulfated glycosaminoglycans, and these interactions increase the affinity of FGF R4 for its ligands as well as its signaling capacity. FGF19 induced signaling through FGF R4 is important for the regulation of bile acid synthesis and lipid and glucose homeostasis. FGF R4 supports glucose tolerance and insulin sensitivity and protects against hyperlipidemia. It is downregulated in the liver during fasting and is upregulated by insulin. It can exert either proliferative or apoptotic effects on hepatocytes. FGF R4 signaling is additionally required for skeletal muscle development in limbs. FGF R4 interacts in cis with cell surface MMP14, leading to downregulation of both proteins.
- 应用类型
- WB
- 免疫原
- 该Anti-Human FGFR-4的详细信息查看ReliaTech提供的产品说明书。
- 来源宿主
- 该Anti-Human FGFR-4的详细信息查看ReliaTech提供的产品说明书。
- 反应性
- 该Anti-Human FGFR-4的详细信息查看ReliaTech提供的产品说明书。
- 保存建议
- 该Anti-Human FGFR-4的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- 其他
- ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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