The monoclonal antibody reacts with human CD156c, which is also known as a disintegrin and metalloproteinase domain-containing protein (ADAM) 10. This type I transmembrane glycoprotein is expressed ubiquitously on hematopoietic and non-hematopoietic cell types. Studies demonstrate that CD156c expression is regulated by PAX2 in cancer cells. CD156c plays a critical role in hematopoiesis, including lymphocyte development, and autoimmunity by regulating the shedding and secretion of various receptors and chemokines, including Notch, CD23, CXCL16, and the IL-6R. Finally, deregulated CD156c expression has been associated with T-cell acute lymphoblastic lymphoma (T-ALL) and Alzheimer’s disease.
应用类型
WB
免疫原
该Anti-Human ADAM-10的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human ADAM-10的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human ADAM-10的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human ADAM-10的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
