Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versus COX-2.{8244,11294} However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example.{9730} CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 µM.{12251} CAY10452 is thus a clean, selective tool for the inhibition of COX-2.
产品描述
A celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM)
