- 中文名称
-+)-AS 115 (5 mg)
- 英文名字
- -+)-AS 115, N-[2-[[(1S,2R)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-2-fluorophenyl ester-carbamic acid
- 供应商
- Cayman
- 产品货号
- 10009650-5
- 产品报价
- ￥21070/5 mg
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- KIAA1363 is a 2-acetyl monoacylglyceryl ether -MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SK0V-3. Treatment of SKOV-3 cells with 10 uM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e., -+)-AS 115 and --)-AS 115, has not been determined.
- 产品描述
- A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues -IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e,. -+)-AS 115 and --)-AS 115, has not been determined
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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