- 中文名称
Tetradecyl Phosphonate (5 g)
- 英文名字
- Tetradecyl Phosphonate, tetradecylphosphonic acid
- 供应商
- Cayman
- 产品货号
- 10007565-5
- 产品报价
- ￥5880/5 g
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Lysophosphatidic acid -LPA) is a lipid signalling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D, also known as autotaxin -ATX). LPA signals through four different G protein-coupled receptors, LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23. Activation of peroxisome proliferator-activated receptor .gamma. -PPAR.gamma.) by LPA has also been reported. Tetradecyl phosphonate is a pan-antagonist of LPA1, LPA2, and LPA3 receptors with IC50 values for inhibition of LPA-induced calcium mobilization of 10 uM, 5.5 uM, and 3.1 uM, respectively. At a concentration of 10 uM, tetradecyl phosphonate activates a PPAR.gamma. reporter construct 4-fold compared to controls and partially inhibits ATX with an IC50 of approximately 3 uM.
- 产品描述
- A pan-antagonist of LPA1-3 receptors -IC50 = 10, 5.5, and 3.1 uM, respectively)
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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