Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells).{1627} It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.{25053} It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.{25054} Triacsin C can inhibit pancreatic β-cell function by suppressing the mobilization of intracellular calcium.{25055}
产品描述
An inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells) that interferes with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters; acts as a hypotensive vasodilator
产品形式
A crystalline solid
保存建议
建议您在收到Cayman Chemical品牌的Triacsin C (500 µg)产品后置于-20度保存，产品有效期为730天.
