- 中文名称
TGX-221 (100 ug)
- 英文名字
- TGX-221, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
- 供应商
- Cayman
- 产品货号
- 10007349-100
- 产品报价
- ￥602/100 ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Phosphatidylinositol 3-kinase -PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol--3,4)-bisphosphate -PtdIns--3,4)-P2) and PtdIns--3,4,5)-P3). Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are 4 isoforms -p110.alpha., p110.beta., p110.delta., and p100.gamma.), and a p85 regulatory subunit. TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110.beta.. Inhibition appears to occur at the ATP binding site based on the observed increase in IC50 from 5 to ~50 nM at ATP concentrations of 50 uM and 1 mM, respectively. TGX-221 inhibits PtdIns--3,4)-P2 production in platelets with an IC50 of 50 nM. Selective inhibition of PI3K p110.beta. results in defective platelet thrombus formation and defines PI3K as a target for antithrombotic therapy.
- 产品描述
- A potent, selective, and cell permable inhibitor of PI3K p110b; IC50 increases from 5 to ~50 nM at ATP concentrations of 50 uM and 1 mM, respectively; inhibits PtdIns--3,4)-P2 production in platelets with an IC50 value of 50 nM
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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