- 中文名称
抗黑皮质素-4受体多克隆抗体
- 英文名字
- Melanocortin-4 Receptor Polyclonal Antibody
- 供应商
- Cayman
- 产品货号
- 10006355-500
- 产品报价
- ￥3206/500 μl
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Melanocortins are known to exert a broad array of physiological actions including melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis . These actions are mediated -differentially or concurrently) in part by a family of G-protein coupled receptors, the melanocortin receptors 1-5 -MC1R-MC5R). Melanocortin-4 receptor -MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain. Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation. Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. Cayman s MC4R polyclonal antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.
- 应用类型
- WB and IHC -formalin-fixed paraffin-embedded sections); other applications not tested
- 免疫原
- mouse melanocortin-4 receptor amino acids 21-33 -YGLHSNASESLGK)
- 来源宿主
- rabbit
- 反应性
- Human MC4R+|Mouse MC4R+|Rat MC4R+
- 保存建议
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
