Valdecoxib is a non-steroidal anti-inflammatory drug that selectively inhibits COX-2, exhibiting IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay.{8926} The COX-2 selectivity ratio of 30 for valdecoxib in this assay is similar to the ratio of 35 observed for rofecoxib (Item No. 10010260).{8926} COX-2 selective inhibitors, including this compound, have been implicated as risk factors in acute atherothrombotic events.{12702,28282}
产品描述
A selective COX-2 inhibitor that exhibits IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay
