- 中文名称
Tafluprost -free acid) (50 mg)
- 英文名字
- AFP-172, Tafluprost -free acid), 9.alpha.,11.alpha.-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,2-tetranor-prosta-5Z,13E-dien-1-oic acid
- 供应商
- Cayman
- 产品货号
- 10005439-50
- 产品报价
- ￥45570/50 mg
- 产品说明书
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- 产品新闻
- 背景资料
- A number of 17-phenyl trinor prostaglandin F2.alpha. -17-phenyl trinor PGF2.alpha.) derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2.alpha. with the 15,15-difluoro substitution. Tafluprost -free acid) is a very potent FP receptor agonist, with a Ki of 0.4 nM. The ester prodrug forms of tafluprost are also potent ocular hypotensives in monkeys.
- 产品描述
- A number of 17-phenyl trinor PGF2.alpha. derivatives have been approved for the treatment of glaucoma.{8941,8322,8839,9311} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile.{12141} Tafluprost is a 2-series, 16-phenoxy analog of PGF2.alpha. with the 15,15-difluoro substitution. Tafluprost -free acid) is a very potent FP receptor agonist, with a Ki of 0.4 nM.{12141} The ester prodrug forms of tafluprost are also potent ocular hypotensives in monkeys.
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
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