中文名称

Caylin-1 (50 mg)

英文名字

Caylin-1, 4-[4,5-bis(3,4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one

供应商

Cayman

产品货号

10004985-50

产品报价

￥24500/50 mg

产品说明书

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产品新闻

背景资料

Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT-116 cells with an IC50 value of approximately 7 uM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 uM, caylin-1 promotes the growth of HCT-116 cells approximately 20% compared to untreated cells. The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.

产品描述

A nutlin-3 analog; inhibits the growth of HCT-116 cells at high concentrations -IC50 = ~7 uM); promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 uM

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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