- 中文名称
Leptomycin B (50 ug)
- 英文名字
- Elactocin|LMB|Mantuamycin|NSC 364372, Leptomycin B, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,1E,12E,16Z,18E-nonadecapentaenoic acid
- 供应商
- Cayman
- 产品货号
- 10004976-50
- 产品报价
- ￥24304/50 ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 -exportin 1) with nuclear export signals -NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins -export factors). By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation. Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..
- 产品描述
- A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1; inhibits nuclear export of HIV-1 Rev -IC50 = 0.53)
- 产品形式
- 保存建议
- -20
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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