Integrin alpha 4 / beta 7 (CD49d / Ly69) , also known as LPAM-1 (Lymphocyte Peyer´s patch adhesion molecule 1), is a heterodimeric (150 kDa / 130 kDa) integrin complex which mediates lymphocyte homing to Peyer´s patch high endothelial venules and to the intestinal lamina propria. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. Ligands of LPAM-1 are MAdCAM-1, VCAM-1, and fibronectin, but the alpha 4 subunit (CD49d) can mediate also homotypic adhesion.
应用类型
FUNC, FC (QC tested), IP, IHC(F)
免疫原
TK1 cells
来源宿主
大鼠
反应性
Mouse
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.