CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
应用类型
FC (QC tested), IP, WB, ICC
免疫原
Synthetic peptide corresponding to amino acids 151-164 of mouse CD3 zeta.
来源宿主
亚美尼亚仓鼠
反应性
Mouse, Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
