- 中文名称
抗人CD11a纯化的抗体，不含叠氮化物
- 英文名字
- Anti-Hu CD11a Purified Azide Free
- 供应商
- EXBIO
- 产品货号
- 10-210-C100
- 产品报价
- ￥询价/0.1 mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868.
- 产品新闻
- 背景资料
- CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
- 应用类型
- FC (QC tested), IP, FUNC
- 免疫原
- Human thymocytes and T lymphocytes.
- 来源宿主
- Mouse IgG2a
- 反应性
- The antibody MEM-115 recognizes an extracellular epitope in the D1 domain of CD4 antigen, a 55 kDa transmebrane glycoprotein expressed on a subset of T lymphocytes (“helper“ T cells) and also on monocytes, tissue macrophages and granulocytes. It is negative in Western blotting even with non-reduced samples of cell lysates.
- 保存建议
- Store at 2-8°C. Do not freeze.
- 其他
- EXBIO是捷克一家著名的生物试剂公司，专注于流式细胞术配套试剂的开发。自1990年成立以来，EXBIO公司研发和制造的抗体分销全球。目前，EXBIO可提供超过4000种质优、价廉的研究和临床应用抗体，涵盖了血液学，免疫学，癌症，干细胞和细胞生物学等领域，如：CD分子、细胞粘附分子、细胞骨架、凋亡、细胞信号传导、肿瘤标志物、人血型、HLA、生殖等研究用抗体，涉及荧光染料如FITC、PE、PE-Cy5、PE-Cy7、APC、PerCP、PerCP-Cy5.5、Pacific Blue、Pacific Orange、Alexa Fluor 488、Alexa Fluor 647、Alexa Fluor 700、Biotin等多达13种，满足客户各类实验需求。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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