A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. GlucocorticosteroidForm:White to Off-White SolidMelting Point:144-146°CSolubility:Chloroform, Methanol