UBE2D1 (UBCH5A) or ubiquitin-conjugating enzyme E2D1 is a member of the E2 ubiquitin-conjugating enzyme family which is closely related to a stimulator of iron transport (SFT). UBE2D1 is significantly upregulated in livers of iron-overloaded patients with hereditary hemochromatosis (1). UBE2D1 also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF-1a by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases (2). UBE2D1 Protein is ideal for investigators involved in Signaling Proteins Ubiquitin Proteins, Cancer, Cell Cycle, and Neurobiology research.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
