TUBB1 or tubulin-beta 1 protein is a major constituent of microtubules. TUBB1 interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function (1). Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both alpha and beta tubulin monomers. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance (2). TUBB1 Protein is ideal for investigators involved in Signaling Proteins, Microtubule/Actin Associated Proteins, Cardiovascular Disease, and Neurobiology research.
序列
该【干冰】Tubulin Beta (TUBB1) recombinant protein-GST fusion protein - 009-001-U24S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】Tubulin Beta (TUBB1) recombinant protein-GST fusion protein - 009-001-U24S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】Tubulin Beta (TUBB1) recombinant protein-GST fusion protein - 009-001-U24S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
