SNCA is a member of the synuclein family which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain and alpha- and beta-synuclein selectively inhibit phospholipase D2 which is a highly conserved protein that is also abundant in neurons, especially presynaptic terminals (1). SNCA gene is not a major risk factor in familial Parkinson disease (2). SNCA may serve to integrate pre-synaptic signaling and membrane trafficking and SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. SNCA Protein is ideal for investigators involved in Signaling Proteins, Microtubule/Actin Associated Proteins, Cancer, and Neurobiology research.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
