SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin (1). SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair (2). SIRT6 Protein is ideal for investigators involved in Signaling Proteins, Cancer, Cell Cycle, and Inflammation research.
序列
该【干冰】SIRT6 recombinant protein-GST fusion protein - 009-001-T36S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】SIRT6 recombinant protein-GST fusion protein - 009-001-T36S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】SIRT6 recombinant protein-GST fusion protein - 009-001-T36S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
