SIRT3 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT3 being a member of class I. SIRT3 contains an N-terminal mitochondrial targeting signal and a central catalytic domain and localizes in the nuclei and mitochondria (1). SIRT3 has NAD(+)-dependent histone deacetylase activity with specificity for lys16 of H4 and, to a lesser extent, lys9 of H3. SIRT3 can repress transcription of a target gene in vivo when recruited to its promoter. Full-length SIRT3 is transported from the nucleus to the mitochondria during cell stress conditions (2). SIRT3 Protein is ideal for investigators involved in Signaling Proteins, Deacetylase/Demethylase Proteins, Cancer, Cell Cycle, and Inflammation research.
序列
该【干冰】SIRT3 recombinant protein-GST fusion protein - 009-001-T33S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】SIRT3 recombinant protein-GST fusion protein - 009-001-T33S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】SIRT3 recombinant protein-GST fusion protein - 009-001-T33S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
