Cyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle that functions as regulators of CDK kinases. Cyclin E1 activity is required for centrosome duplication during S phase and this mechanism could coordinate centrosome reproduction with cycles of DNA synthesis and mitosis (1). The downregulation of cyclin E-CDK2 kinase activity following the G1/S-phase transition that is necessary for the maintenance of karyotypic stability. Cyclin E also has a modular centrosomal-targeting domain which is essential for promoting S phase entry in a Cdk2-independent manner (2). Cyclin E1 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, and Cell Cycle research.
序列
该【干冰】CyclinE1 recombinant protein-GST fusion protein - 009-001-R79的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】CyclinE1 recombinant protein-GST fusion protein - 009-001-R79的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】CyclinE1 recombinant protein-GST fusion protein - 009-001-R79的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
