CDKL1 or cyclin-dependent kinase-like 1 is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL1, which is also known as p42 KKIALRE, accumulates primarily in the nucleus and is known to regulate important transitions in the eukaryotic cell cycle (1). CDKL1 and the related CDC2 protein kinase have a similar pattern of mRNA expression except in the reproductive organs. CDKL1 is expressed in several human tissues, with the highest expression in kidney and ovary (2). CDKL1 is overexpressed in breast cancer patients and has a positive detection efficiency of 77%. Inhibiting CDKL1 function with shRNA in MCF-7 cells shows increased accumulation of the cells at the G2/M phase and increased sensitivity to cell cycle chemotherapeutic drugs. CDKL1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.
序列
该【干冰】CDKL1 recombinant protein-GST fusion protein - 009-001-R66S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】CDKL1 recombinant protein-GST fusion protein - 009-001-R66S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】CDKL1 recombinant protein-GST fusion protein - 009-001-R66S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
