BID is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2 (1). BID is a member of the BCL-2 family of cell death regulators and is a mediator of mitochondrial damage induced by caspase-8 (CASP8). BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Multiple alternatively spliced transcript variants of BID have been found, but the full-length nature of some variants has not been defined. BID together with Cathepsins play an important role in the actions of Camptothecin on breast cancer cells (2). BID Protein is ideal for investigators involved in Signaling Proteins, Apoptosis Proteins, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, and Neurobiology research.
序列
该【干冰】BID recombinant protein-GST fusion protein - 009-001-R51的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】BID recombinant protein-GST fusion protein - 009-001-R51的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】BID recombinant protein-GST fusion protein - 009-001-R51的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
