IKKgamma is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKKgamma forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha (1). IKKgamma associates with activated ATM after the induction of DNA double-strand breaks (2). ATM phosphorylates serine-85 of IKKgamma to promote its ubiquitin-dependent nuclear export. IKKgamma Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Inflammation, Neurobiology, Ser/Thr Kinases, and WNT Signaling research.
序列
该【干冰】IKK gamma recombinant protein-GST fusion protein - 009-001-H86的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】IKK gamma recombinant protein-GST fusion protein - 009-001-H86的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】IKK gamma recombinant protein-GST fusion protein - 009-001-H86的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
