CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.Appearance:Off-White to Light Grey SolidPurity:~90%Atmoshpere: Inert gasMelting Point:238-243°C (dec.)Solubility:DMSO, MethanolMethod for Determining Identity:Proton NMR (DMSO-d6, CD3OD) Spectroscopic and Mass Spectrometric AnalysisTLC Conditions:As ReportedChloride Content:As ReportedElemental Analysis:As ReportedStorage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
