Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis. Melting Point:164-166ºCSolubility:DMSO (Slightly)Method for Determining Identity:Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric AnalysisTLC Conditions:SiO2; Tetrahydrofuran: Ammonium Hydroxide =9.5:0.5; Visualized with UV and AMCS; Single spot, Rf=0.50Elemental Analysis: Calculated: %C: 79.46, %H: 4.67Atmosphere:Inert gasStorage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert atmosphere.Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
