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Relia Tech:活性VEGF,VEGFR重组蛋白

发布者:艾美捷科技    发布时间:2022-07-26     
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新血管的形成(angiogenesis)是肿瘤生长转移和传播过程中的一种基本活动。因此,在癌症研究领域,人们对研究肿瘤血管生成的分子机制十分感兴趣。而血管内皮生长因子(vascular endothelial growth factor,VEGF)路径是这一过程的关键调节者。   


血管内皮生长因子


VEGF(vascular endothelial growth factor,血管内皮生长因子)/VEGFR(vascular endothelial growth factor receptor,血管内皮生长因子受体)轴由多重配基和受体质量叠加交错组成,并且受体与配基结合具有专一性,在不同的细胞中具有不同的细胞类型表达和功能,启动VEGFR信号通路,触发了一个网状的信号过程,从而促进血管内皮细胞生长、转移和存活。VEGF/VEGFR也是目前研究最多的一条信号通路,并取得了显著的成果。

作为专业的生命科学医药原料和解决方案供应商,艾美捷科技为您推荐来自德国,Relia Tech荣誉出品:活性VEGF,VEGFR重组蛋白 


货号中文名称来源规格氨基酸(a.a)Uniprot
RET-M30-032重组蛋白, 小鼠, VEGF120大肠杆菌20ug120Q00731
RET-R20-064重组蛋白, 大鼠, VEGF120大肠杆菌20ug120P16612
RET-300-072重组蛋白, 人, VEGF121大肠杆菌20ug121P15692
RET-300-032重组蛋白, 人, VEGF121昆虫细胞20ug121P15692
RET-M30-034重组蛋白, 小鼠, VEGF144大肠杆菌20ug144Q00731
RET-300-033S-E重组蛋白, 人, VEGF145大肠杆菌2ug145P15692
RET-300-034-E重组蛋白, 人, VEGF145大肠杆菌20ug145P15692
RET-M30-004重组蛋白, 小鼠, VEGF164大肠杆菌20ug164Q00731
RET-M30-002重组蛋白, 小鼠, VEGF164昆虫细胞20ug164Q00731
RET-R20-068重组蛋白, 大鼠, VEGF164大肠杆菌20ug164P16612
RET-300-076重组蛋白, 人, VEGF165大肠杆菌20ug164P15692
RET-300-036重组蛋白, 人, VEGF165昆虫细胞20ug165P15692
RET-300-082重组蛋白, 人, VEGF165b大肠杆菌20ug164P15692-8
RET-300-065Bi重组蛋白, 人, VEGF165-生物素大肠杆菌10ug165P15692
RET-300-066Bi重组蛋白, 人, VEGF165-生物素大肠杆菌25ug165P15692
RET-M30-095重组蛋白, 小鼠, VEGF188大肠杆菌20ug188Q00731
RET-R20-070重组蛋白, 大鼠, VEGF188大肠杆菌20ug188P16612
RET-300-095重组蛋白, 人, VEGF189大肠杆菌20ug189P15692
RET-300-099重组蛋白, 人, VEGF206大肠杆菌20ug206P15692
RET-300-080重组蛋白, 人, VEGF-B167大肠杆菌20ug167P49765
RET-300-079重组蛋白, 人, VEGF-C昆虫细胞20ug121P49767
RET-R20-015重组蛋白, 大鼠, VEGF-C昆虫细胞20ug127O35757
RET-R20-017重组蛋白, 大鼠, VEGF-C152S昆虫细胞20ug127O35757
RET-300-045重组蛋白, 羊口疮病毒, VEGF-E大肠杆菌20ug132Q9YMF3
RET-300-046重组蛋白, 羊口疮病毒,  VEGF-E,  肝素结合域昆虫细胞20ug154Q9YMF3
RET-300-097重组蛋白, 蛇,  VEGF-F (矛头蝮)大肠杆菌20ug124Q90X24
RET-S01-016重组蛋白, 人, VEGFR-1/Flt-1 (D3), 可溶性蛋白昆虫细胞20ug327P17948
RET-S01-080重组蛋白, 人, VEGFR-1/Flt-1 (D3)-His, 可溶性蛋白昆虫细胞50ug327P17948
RET-S01-014重组蛋白, 人, VEGFR-1/Flt-1 (D4), 可溶性蛋白昆虫细胞20ug457P17948
RET-S01-012重组蛋白, 人, VEGFR-1/Flt-1 (D5), 可溶性蛋白昆虫细胞20ug536P17948
RET-S01-010重组蛋白, 人, VEGFR-1/Flt-1(天然), 可溶性蛋白昆虫细胞20ug661P17948
RET-S01-072重组蛋白, 人, VEGFR1-14/Flt1-14, 可溶性蛋白昆虫细胞20ug707P17948-3
RET-SFC-006重组蛋白, 人, VEGFR-1/Flt-1(D7)-Fc 嵌合体, 可溶性蛋白昆虫细胞50ug954P17948
RET-SFC-M06重组蛋白, 小鼠, VEGFR-1/Flt-1(D7)-Fc 嵌合体, 可溶性蛋白昆虫细胞50ug965P17948
RET-S01-002重组蛋白, 人, VEGFR-2/KDR (D7), 可溶性蛋白昆虫细胞50ug738P35968
RET-S01-004重组蛋白, 人, VEGFR-2/KDR(天然), 可溶性蛋白昆虫细胞20ug659P35968
RET-SFC-008重组蛋白, 人, VEGFR-2/KDR-Fc 嵌合体, 可溶性蛋白昆虫细胞50ug968P35968
RET-S01-M04重组蛋白, 小鼠, VEGFR-2/Flk-1(天然), 可溶性蛋白昆虫细胞20ug654P35918
RET-S01-018重组蛋白, 人, VEGFR-3/FLT-4, 可溶性蛋白昆虫细胞50ug761P35916
RET-SFC-010重组蛋白, 人, VEGFR-3/FLT-4/Fc 嵌合体, 可溶性蛋白昆虫细胞50ug979P35916

* 以上蛋白产品,均为冻干粉形式.* 蛋白分子量与序列详情,欢迎垂询艾美捷客服. 

VEGF蛋白 SDS-PAGEVEGF蛋白刺激HUVEC增殖

  【VEGF/VEGFR产品发表文章】

  • Cudmore, M., Hewett, P., Ahmad, S. et al. The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis. Nat Commun 3, 972 (2012). https://doi.org/10.1038/ncomms1977

  • Teichert, M., Milde, L., Holm, A. et al. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun 8, 16106 (2017). https://doi.org/10.1038/ncomms16106

  • SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes. R. Atallah et al., Int J Mol Sci. 2021 Nov; 22(21): 12048.

  • Transforming growth factor‐β1 signalling triggers vascular endothelial growth factor resistance and monocyte dysfunction in type 2 diabetes mellitus. L.‐M. Makowski et al., J Cell Mol Med. 2021 Jun; 25(11): 5316–5325.

  • Outgrowth, proliferation, viability, angiogenesis and phenotype of primary human endothelial cells in different purchasable endothelial culture media: feed wisely. B. Leopold et al., Histochem Cell Biol. 2019; 152(5): 377–390.

  • Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Qi Chen et al., Cell Stem Cell. 2019 Dec 5; 25(6): 768–783.e6.

  • BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation. E. Pardali et al., J Cell Mol Med. 2018 Nov;22(11):5429-5438.

  • Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential.  Tasev D et al., Front Med (Lausanne). 2018 Dec 20;5:356.

  • Blood Outgrowth and Proliferation of Endothelial Colony Forming Cells are Related to Markers of Disease Severity in Patients with Pulmonary Arterial Hypertension. Smits J et al., Int J Mol Sci. 2018 Nov 27;19(12). pii: E3763.

  • Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. H. M. Eilken et al., Nat Commun. 2017; 8: 1574.

  • CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs). D. Tasev et al., Angiogenesis. 2016; 19: 325–338.

  • Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature. Lohr J et al., Anticancer Res. 2015 May;35(5):2681-90.

  • Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity. D. Tasev et al., PLoS One. 2015; 10(6): e0129935.

  • The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib?). A. K.A. Gaumann et al., Int J Oncol. 2014 Dec; 45(6): 2267–2277.

  • Improved Anchorage of Ti6Al4V Orthopaedic Bone Implants through Oligonucleotide Mediated Immobilization of BMP-2 in Osteoporotic Rats. J. V. W?lfle et al., PLoS One. 2014; 9(1): e86151.

  • Spatial regulation of VEGF receptor endocytosis in angiogenesis. M. Nakayama et al., Nat Cell Biol.2 13 Mar; 15(3): 249–260.

  • Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity. N. Izumi et al., PLoS One. 2012; 7(7): e41116.

  • The Antiangiogenic 16K Prolactin Impairs Functional Tumor Neovascularization by Inhibiting Vessel Maturation. Ngoc-Quynh-Nhu Nguyen et al., PLoS One. 2011; 6(11): e27318.

  • MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells. C. Sabatel et al., PLoS One. 2011; 6(2): e16979.

  • Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis. S. Ahmad et al., Vasc Cell. 2011; 3: 15.

  • Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit: THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS. V. Caolo et al., J Biol Chem. 2010 Dec 24; 285(52): 40681–40689.

  • Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes. J. M. van Golde et al., Diabetes. 2008 Oct; 57(10): 2818–2823.

  • Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. S. Ahmad and A. Ahmed Circ Res. 2004 Oct 29;95(9):884-91.

  • Collagen type 1 retards tube formation by human microvascular endothelial cells in a fibrin matrix. Kroon, M.E. et al., Angiogenesis (2002) 5: 257.


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热销:FGF2、a-mLYVE1、VEGF等活性重组蛋白【已发表文章超1000篇】,2800+细胞培养级低内毒素重组蛋白和抗体,专注受体与配体研究,适合用于VEGF靶向药物研发、生物制药原材料。 

https://www.amyjet.com/brand/ReliaTech.shtml 

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