Cell permeable geldanamycin analogue that displays superior pharmacological properties. Inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Hsp90 inhibition leads to autophagy activation resulting in the degradation of substrates such as the NFkB pathway activator IKK.
产品描述
Inhibitor of Hsp90 chaperone activity. Geldanamycin analogue. Autophagy activator