Homeobox protein MOX-2 （MEOX2） is a part of a family of nonclustered， diverged homeobox genes which are expressed in overlapping patterns in the paraxial mesoderm and its derivatives. MEOX2 participates in the regulation of vertebrate limb myogenesis. MEOX2 also takes part in mesoderm induction and its earliest regional specification， somitogenesis， myogenic and sclerotomal differentiation. Mutations in the related mouse MEOX2 are related with craniofacial and/or skeletal abnormalities， in addition to neurovascular dysfunction observed in Alzheimer’s disease.
