Dickkopf-related protein 2 （DKK2） is a member of the dickkopf family， which has a vital role in vertebrate development， where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning， limb development， somitogenesis and eye formation. In adults， Dkks are involved in bone formation and bone disease， cancer and Alzheimer disease. DKK2 contains 2 cysteine rich regions and is implicated in embryonic development through its interactions with the Wnt signaling pathway. DKK2 may function as either an agonist or antagonist of Wnt/beta-catenin signaling， depending on the cellular environment and the presence of the co-factor kremen 2. DKK2 protein activity is also controlled by binding to the Wnt co-receptor LRP6 （LDL-receptor related protein 6）.
