TXNRD1 belongs to the selenium-containing pyridine nucleotide-disulphide oxidoreductase family， which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. TXNRD1 decreases thioredoxins as well as other substrates， and participates in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity serves as a potential treatment for cancer， AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
