FTY 720 P是新型免疫抑制药物芬戈莫德（FTY 720）的生物活性形式。FTY 720通过鞘氨醇激酶转化为FTY 720 P，（S）-异构体作为四种S1 P受体（S1 P1 3 4 5）的激动剂，IC 50分别为2.1、5.9、23和2.2 nM。R异构体以低5-10倍的亲和力结合。FTY 720 P通过细胞外信号调节激酶（ERK）信号通路促进新生大鼠少突胶质细胞存活、调节少突胶质细胞祖细胞分化、促进星形胶质细胞迁移。最近发表的结果表明，FTY 720 P参与淋巴脉络丛脑膜炎病毒（LCMV）克隆13引起的持续性感染的完全病毒清除。出版物由Bioz提供技术支持查看Bioz 1的更多详情。布基河 等（2010年）。“血浆凝溶胶蛋白调节细胞对1-磷酸鞘氨醇的反应。“美国生理学杂志细胞生理学299（6）：C1516-1523.2。古Y。 等（2011年）。“上皮细胞挤出需要鞘氨醇-1-磷酸受体2途径。《细胞生物学杂志》193（4）：667-676.3。特尔科夫湾 等（2012年）。芬戈莫德-一种鞘氨醇样分子抑制星形胶质细胞中囊泡的流动性和分泌。“Glia 60（9）：1406.4。萨穆韦尔湾等（2015）. AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.“PLoS ONE 10（10）：e0141781.5.巴以法莲E. 等（2019）。CD 62 L是循环先天类淋巴细胞前体的功能和表型标志物。《免疫学杂志》202（1）：171-182。
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FTY720P is the bioactive form of the novel immunosuppressive drug fingolimod (FTY720). FTY720 is converted to FTY720P by sphingosine kinase and the (S)-isomer acts as an agonist to four S1P receptors (S1P1 3 4 5) with IC50s of 2.1 5.9 23 and 2.2 nM respectively. The R isomer binds with 5-10 fold lower affinity. FTY720P improves the survival of neonatal rat oligodendrocytes regulates oligodendrocyte progenitor cells differentiation promotes astrocyte migration via extracellular signal-regulated kinase (ERK) signaling. Recently published results indicate involvement of FTY720P in complete viral clearance of persistent infection caused by clone 13 of lymphotic choriomeningitis virus (LCMV).Publications Powered by Bioz See more details on Bioz1. Bucki R. et al. (2010). "Plasma gelsolin modulates cellular response to sphingosine 1-phosphate." Am J Physiol Cell Physiol 299(6): C1516-1523.2. Gu Y. et al. (2011). "Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway." The Journal of Cell Biology 193(4): 667-676.3. Trkov S. et al. (2012). "Fingolimod—A sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes." Glia 60(9): 1406.4. Samuvel D. J. et al. (2015). "AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis." PLoS ONE 10(10): e0141781.5. Bar-Ephraim Y. E. et al. (2019). "CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors." The Journal of Immunology 202(1): 171-182.
