SH 2-结构域肌醇5-磷酸酶（SHIP 1 SHIP 2）使PI（3 4 5）P3的5位去磷酸化，产生PI（3 4）P2。PI（3 4）P2激活蛋白激酶B（PKB/Akt）并促进细胞存活。SHIP 2在结直肠癌中的表达和活性增加，表明其具有致癌作用。用K149（2 μ M）处理结肠直肠癌细胞降低PKB/Akt信号传导并使细胞对5-氟尿嘧啶敏感，而不管细胞系是否具有PI 3 KCA突变。Hoekstra A.H. Das et al.“Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation”Oncotarget 2016; 7：73525-73540.DOI：10.18632/onctarget.12321
产品描述
SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3 4 5)P3 generating PI(3 4)P2. PI(3 4)P2 activates Protein Kinase B (PKB/Akt) and promotes cell survival. SHIP2 expression and activity is increased in colorectal cancer suggesting an oncogenic role. Treatment of colorectal cancer cells with K149 (2uM) decreases PKB/Akt signaling and sensitizes the cells to 5-fluorouracil regardless of whether the cell lines have a PI3KCA mutation.References1) E. Hoekstra A.H. Das et al. “Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation†Oncotarget 2016; 7:73525-73540. DOI: 10.18632/oncotarget.12321
