白藜芦醇是一种IA类PI3K抑制剂，可激活SIRT1并对人乳腺上皮细胞显示抗增殖作用。白藜芦醇通过线粒体膜去极化和caspase-9激活诱导细胞凋亡。此外，白藜芦醇抑制核糖核苷酸还原酶和DNA合成，环氧合酶-1 PKD和类花生酸合成。参考文献1）S Fröjdöet al. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J. 406 511（2007）2）K.T. Howitz等人，Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifetime. 3）O.P.Mgbonyebi等人，合成白藜芦醇对人乳腺上皮细胞的抗增殖作用。国际肿瘤学杂志12 865（1998）3）J.Dorrie等，Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res.614731（2001）4）M.白藜芦醇是核糖核苷酸还原酶的显著抑制剂。FEBS Lett. 421 277（1998）白藜芦醇的癌症化学预防活性，一种来自葡萄的天然产物。6）J.R.白藜芦醇对佛波酯反应性蛋白激酶自磷酸化的影响：抑制蛋白激酶D但不抑制蛋白激酶C同工酶自磷酸化。Biochem. Pharmacol. 60 1355（2000年）
产品描述
Resveratrol is a class IA PI3K inhibitor activates SIRT1 and displays antiproliferative effect on human breast epithelial cells. By depolarization of mitochondrial membrane and caspase-9 activation resveratrol induces apoptosis. In addition Resveratrol inhibits ribonucleotide reductase and DNA synthesis cyclooxygenase-1 PKD and eicosanoid synthesis.References1) S Fröjdö et al. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J. 406 511 (2007)2) K.T. Howitz et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191 (2003)3) O.P. Mgbonyebi et al. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12 865 (1998)3) J. Dorrie et al. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61 4731 (2001)4) M. Fontecave et al. Resveratrol a remarkable inhibitor of ribonucleotide reductase. FEBS Lett. 421 277 (1998)5) M. Jang et al. Cancer chemopreventive activity of resveratrol a natural product derived from grapes. Science 275 218-220 (1997)6) J.R. Stewart et al. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem. Pharmacol. 60 1355 (2000)
