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ELISA试剂盒
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中文名称

大内皮素Elisa试剂盒

英文名字
Big Endothelin-1 ELISA Kit
供应商
Biomedica Immunoassays
产品货号
BI-20082H
产品报价
¥12x8tests
产品说明书
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产品新闻
背景资料
Big Endothelin-1 (BigET-1) is a peptide of 38 amino acids and is the precursor of Endothelin-1 (ET-1), consisting of amino acids 1-21 (http://www.uniprot.org/uniprot/P05305). ET-1 is a potent vasoconstrictor and is produced by vascular endothelial cells. Accordingly, it has a wide tissue distribution (http://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.511899). The cleavage of BigET-1 by the Endothelin-converting enzyme (ECE) converts BigET-1 to Endothelin (ET) and to a C‑terminal fragment.

The half-life of ET-1 (1-21) in plasma is less than one minute, which may preclude its use as a diagnostic marker, whereas clearance of the precursor peptide BigET-1 is much slower. As Big-Endothelin-1 is produced at amounts equimolar to ET-1 and has higher plasma stability, it is more suitable for diagnostics and monitoring of heart failure (Gergei et al., 2018). Hence, Big ET-1 has the same physiological role as ET-1 while being a more reliable marker.
产品描述
Method Sandwich ELISA, HRP/TMB, 12×8-well detachable strips Sample type Serum, EDTA plasma. citrate plasma, heparın plasma Sample volume 50 µl / well Assay time 4 h / 1 h / 30 min Sensitivity 0.02 pmol/l (= 0.086 pg/ml) Standard range 0 – 3 pmol/l (= 0 – 12.85 pg/ml) Conversion factor 1 pmol/l = 4.283 pg/ml (MW: 4.283 kDa) Precision In-between-run (n=5): ≤ 5 % CV Within-run (n=10): ≤ 4 % CV Specificity Endogenous and recombinant Big Endothelin-1 (Big ET-1 (1-38)). Cross-reactivity Human ET1/2/3 (1-21): <1%, human ET2 (1-37): <1%, human ET1/2 (1-38): <1%, human BigET1/2 (22-38) : <1%, human BigET2 (22-37) : <1%, porcine BigET (1-39): 21%, rat BigET1 (1-39): 10%, Sarafotoxin: <1%
产品特点
保存建议
+4°C
其他
Biomedica Immunoassay(bmgrp)公司成立于1988年, 总部位于奥地利维也纳,主要致力于研究、开发和生产基于ELISA方法用于临床前研究相关标记物检测的工具。迄今为止Biomedica Immunoassay公司在心血管检测及骨代谢检测领域开发了一系列特色ELISA检测试剂盒,Biomedica Immunoassay的生产过程符合GMP/GLP指南,并符合ISO 9001:2015管理体系,有CE认证。Biomedica Immunoassay的产品根据FDA, EMEA和ICH指南进行验证,并具有验证报告。
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