PSMA is a cancer antigen that is widely expressed as a noncovalent homodimer on the surface of prostate cancer cells， rather than on normal cells， therefore it is an interesting target to image prostate tissues when being used with radioactive antibodies. PSMA is expressed on the surface of novel blood vessels that nourish a broad range of other solid tumors. PSMA is a type II membrane protein with folate hydrolase activity produced by prostatic epithelium. PSMA expression is found in extraprostatic tissues， including small bowel and brain.
应用类型
ELISA， Western blot
免疫原
Anti-human PSMA mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PSMA amino acids 117-351 purified from E. coli.
