FGA encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in FGA lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. FGA (Fibrinogen Alpha Chain) is a Protein Coding gene. Diseases associated with FGA include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and RET signaling.
