Beta-catenin associates with the cytoplasmic portion of E-cadherin，which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues，beta-catenin is localized to the membrane of epithelial cells，consistent with its role in the cell adhesion complex. In breast ductal neoplasia，beta-catenin is usually localized in cellular membranes. However，in lobular neoplasia，a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms，including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally，some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining，mimicking the staining pattern observed with lobular breast carcinomas.
应用类型
FC, IF, IHC, WB
免疫原
Recombinant human full-length beta-Catenin (p120) protein fragment
