Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.
应用类型
WB, N
免疫原
该Anti-Human Junctional adhesion molecule C (JAM-C)的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human Junctional adhesion molecule C (JAM-C)的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human Junctional adhesion molecule C (JAM-C)的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human Junctional adhesion molecule C (JAM-C)的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
