IkB-beta is part of the NFkB complex and it inactivates NFkB complex by binding to it and trapping it in the cytoplasm. Phosphorylation of serine residues on IkB-beta mediated by IkB kinases leads to its destruction via the ubiquitination pathway thereby allowing activation of the NFkB complex which translocates into the nucleus and binds DNA at kappa-B-binding motifs (1). The PEST domain of IkB-beta can interact with two proteins KBRAS1 and KBRAS2 and this interaction can decrease the rate of degradation IkB-beta. IkBβ has been shown to participate in multiple signaling pathways including adipocytokine signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway and Hypoxia (2). IkB-beta Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, and p38 Pathway research.
序列
该【干冰】I kappaB beta recombinant protein-GST fusion protein - 009-001-S19的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】I kappaB beta recombinant protein-GST fusion protein - 009-001-S19的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】I kappaB beta recombinant protein-GST fusion protein - 009-001-S19的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
