HCV is a small 50nm， enveloped， single-stranded， positive sense RNAvirus in the family Flaviviridae.
HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase， the HCV has an exceptionally high mutation rate， a factor that may help it elude the host’s immune response. Hepatitis C virus is classified into six genotypes（1-6） with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes （2， 3， 5 and 6）.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的重组丙型肝炎病毒NS5，基因型3产品为溶液形式.该产品已溶解在含1mM EDTA， 1.5M 尿素和50%甘油的25 mM Tris-HCl缓冲液（pH 8）.
保存建议
Five years frozen. One month in solution at room temperature.
