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一抗
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中文名称

ET-B抗体(0.2 ml)

英文名字
Anti-ET-B
供应商
Alomone
产品货号
ALO-AER-002-0.2
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
Endothelins (ET-1, 2, and 3) are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein coupled receptors, ETAR and ETBR. Both ETAR and ETBR are present in the heart and in human myocardium at similar levels.nThe endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity.nSubsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities.Currently there is increasing evidence that ET-1 may modulate mitogenesis, apoptosis, angiogenesis tumor invasion and the development of metastases.3nUntil recently, it was thought that all cellular activities of the endothelins were mediated through their interactions with their cell surface receptors. However, a recent study demonstrated that cardiac nuclei also possess both ETAR and ETBR subtypes, which are functional and coupled to signaling mechanisms within the nuclear membrane.nHypermethylation of the ETBR correlated with transcriptional down-regulation and reduced expression of ETB receptor was observed in several prostate, bladder and colon cancer cell lines.
应用类型
经验证,该抗体可应用于IC、IH、WB等实验应用,也可用于IFC、IP等实验。
免疫原
ET-B抗体的免疫原肽段为CEMLRKKSGMQIALND。此免疫原序列来源于298-314 位氨基酸残基,该序列来源于大鼠ET-B (Accession编号为P21451),第三胞内环。
来源宿主
反应性
反应性:人、 小鼠、 大鼠
保存建议
艾美捷为您提供的ET-B抗体(0.2 ml)为室温运输,建议您收到产品后﹣20℃保存。
其他
Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
注意
该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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