- 中文名称
Proteinase 3, Human (PRTN3, Neutrophil)
- 英文名字
- Proteinase 3, Human (PRTN3, Neutrophil)
- 供应商
- USBiological
- 产品货号
- 209162
- 产品报价
- ¥1/25ug
- 产品说明书
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- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商,生产世界上种类最多的抗体,用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理,是行业中少有的致力于服务客户,帮助客户,且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应,专业的产品和解决方案支持,稳健快捷的交货周期,优质放心的售后服务。我们致力于为您提供有价值的产品和服务,在意您的成功!
- 产品描述
- Proteinase 3 also known as PRTN3 is an enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.Anti-neutrophil cytoplasmic antibodies (ANCAs) are autoantibodies produced in response to neutrophil cytoplasmic enzymes, and evaluating the levels of ANCAs is useful for making a diagnosis of systemic vasculitis such as granulomatosis with polyangiitis (Wegener’s) (GPA) or microscopic polyarteritis (MPA). The majority of p-ANCAs and c-ANCAs have been proven to be equivalent to MPO- and PR3- ANCAs, respectively. Patients with MPA and Churg- Strauss syndrome are positive for p-ANCA, and those with GPA are positive for c-ANCA (3-5). In patients with active systemic GPA, MPA or Churg-Strauss syndrome, ANCAs are reported to be positive in over 80%, 70% or 50% of cases, respectively. Moreover, as ELISA provides a good detection rate and useful results, we analyzed the levels of MPO- and PR3- ANCAs to make a diagnosis of systemic vasculitis in the current clinical setting.Source:Proteinase-3, from human plasmaMolecular Weight:~29kDApplications: Suitable for use in ELISA and Western Blot. Other applications not tested.Recommended Dilution:ELISA: 1:10K-1:100K; using 50-100ng of control peptide/wellWestern Blot: 100-500ng/laneOptimal dilutions to be determined by the researcher.Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- 产品形式
- 该产品为冻干粉 in 50mM MES, pH 4.5, 700mM sodium chloride,缓冲液为:sterile ddH2O or other buffers。
- 保存建议
- 接收到Proteinase 3, Human (PRTN3, Neutrophil)产品后,置于-20°C温度下保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商,生产世界上种类最多的抗体,用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品,为科研用户提供了诸多超值选择。
- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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