Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential cation channel 3 (TRPC3).{27896} It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM.{27896} Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.{27896}
产品描述
A selective TRPC3 inhibitor that prevents TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) without effect on other TRPC members; suppresses activation of NFAT (IC50 = 0.05 μM) and attenuates cardiac hypertrophy in mice at 0.1 mg/kg/day
